School of Medicine Publications and Presentations
Genetics of cardiovascular disease in minority populations
Document Type
Book Chapter
Publication Date
1-1-2015
Abstract
Cardiovascular disease (CVD) is a growing health problem in many minority populations, including Mexican Americans, American Indians, and Alaskan Eskimos. In studies of extended families in these three populations, our goal is to identify genetic factors that influence risk of CVD and related traits and to understand the interactions of genes with environmental factors. Many CVD risk factors have been shown to be significantly heritable, and linkage analyses have identified chromosomal regions that harbor quantitative trait loci (QTLs) influencing CVD risk. Genetic correlations and genotype x environment interactions have been demonstrated for numerous phenotypes related to CVD. Fine mapping using single nucleotide polymorphisms (SNPs) is being done in chromosomal regions with high LOD scores for specific disease risk factors. Exomes and whole genomes are being sequenced, and efforts are underway to identify the relevant functional genes using genome-wide association, transcriptomic analysis, and other approaches.
Recommended Citation
MacCluer, J.W., Blangero, J., Comuzzie, A.G., Ebbesson, S.O.E., Howard, B.V., Cole, S.A. (2015). Genetics of Cardiovascular Disease in Minority Populations. In: Duggirala, R., Almasy, L., Williams-Blangero, S., Paul, S., Kole, C. (eds) Genome Mapping and Genomics in Human and Non-Human Primates. Genome Mapping and Genomics in Animals, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46306-2_11
First Page
155
Last Page
179
Publication Title
Genome Mapping and Genomics in Human and Non-Human Primates
DOI
10.1007/978-3-662-46306-2_11
Academic Level
faculty
Mentor/PI Department
Office of Human Genetics
Comments
© 2015 Springer-Verlag Berlin Heidelberg
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