School of Medicine Publications and Presentations
Multi Site Comparison of Participant Profiles in the South Texas Alzheimer’s Disease Research Center
Document Type
Article
Publication Date
1-3-2025
Abstract
Background
Hispanic adults comprise 19% of the US population, yet 400% increase in ADRDs in this population is anticipated over the next twenty-five years. Knowledge is limited on the prevalence and influence of social determinants of health (SDoH) and modifiable risk factors on cognition in ethnically diverse groups. The South Texas Alzheimer’s Disease Research Center (STAC, P30AG066546) is a collaboration between UT Health San Antonio (UTHSA) and UT Rio Grande Valley (UTRGV) with a primary aim to better understand ADRDs in Hispanic adults. Our objective is (1) to describe differences in SDoH, modifiable risk factors, and cognitive performance in cognitively unimpaired adults in STAC, and (2) to assess differences between sites to better understand the risk factors in ADRDs in Hispanics by location.
Method
Participants in San Antonio, Tx, and Rio Grande Valley, Tx completed cognitive testing and questionnaires of medical history, SDoH, and modifiable ADRD risk factors. The two sites were compared between sites with Wilcoxon and T-Tests. Differences in neurocognitive performance was further assessed with linear regression adjusting for age, sex, and education.
Result
Cognitively unimpaired adults were enrolled at UTHSA (n = 180, mean(SD) age 71(10), 36% male, 47% Hispanic) and UTRGV (n = 45, age 63(12), 33% male, 71% Hispanic). Participants at UTRGV were younger and more frequently identified as Hispanic. Site differences were seen on Trails B (p < 0.001), and Number Span Total Forward (p = .001) and Total Backward (p = 0.009) after adjusting for age, sex, and education. Sites showed differences in risk factors including hyperlipidemia (p =
Conclusion
Overall, there were significant differences in the risk factors between locations, supporting the value of recruiting participants at both sites to assess the spectrum of risk factors and SDoH in Hispanic adults.
Recommended Citation
Bosque, J. G. D., Wang, C. P., Fernandez, R. A., Tanner, J. A., Sullivan, A. C., Savoia, S. E., Parker, A. S., Salardini, A., de Erausquin, G. A., Goss, M., Trevino, H. A., Patel, A. N., Katragadda, H. V., Seidl, A. M., Saklad, A. R., Werry, A., Gonzales, M. M., Pirela‐Mavarez, R. P., Mejia‐Arango, S., Lavigne, S., … LaRoche, A. (2025). Multi Site Comparison of Participant Profiles in the South Texas Alzheimer’s Disease Research Center. Alzheimer's & Dementia, 20(Suppl 3), e091760. https://doi.org/10.1002/alz.091760
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Alzheimer's & Dementia
DOI
10.1002/alz.091760
Academic Level
faculty
Mentor/PI Department
Neuroscience
Comments
© 2024 The Alzheimer's Association. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.