School of Medicine Publications and Presentations
Document Type
Article
Publication Date
9-4-2024
Abstract
Background: The intestinal microbiome has been recently linked to several metabolic and chronic disorders, one of which is coronary artery disease (CAD). Our study aimed to analyze the intestinal microbiome of CAD patients and assess the eligibility of dysbiosis as a diagnostic marker of CAD.
Methods: PubMed, Scopus, Embase, and Web of Science were searched using terms, such as 'CAD' and 'microbiome'. Only observational controlled studies were included. R version 4.2.2 was used for the analysis.
Results: A significant association was found between the CAD group and increased Simpson and Shannon Indices compared with the control group (MD=0.04, 95% CI=0.03-0.05, and MD=0.11, 95% CI=0.01-0.22, respectively). Our analysis yielded a statistically significant association between the CAD group and increased Prevotella genus (MD=13.27, 95% CI=4.12-22.42, P-value=0.004), Catenibacterium genus (MD=0.09, 95% CI=0.09-0.10), Pseudomonas genus (MD=0.54, 95% CI=0.29-0.78, P-value), and Subdoligranulum (MD=-0.06, 95% CI=-0.06 to -0.06) compared with the control group. Another significant association was detected between the CAD group and decreased Bacteroides vulgatus and Bacteroides dorei (MD=-10.31, 95% CI=-14.78 to -5.84, P-value < 0.00001).
Conclusion: Dysbiosis is an acceptable diagnostic marker of CAD. Decreased B. dorei and B. vulgatus among CAD patients suggests a protective role of these bacteria. Future clinical trials are necessary to investigate the potential benefit of supplementation of these bacteria in treating or preventing CAD.
Recommended Citation
Dean, Y. E., Shebl, M. A., Doma, M., Elmezayen, R. W., Loayza Pintado, J. J., Rouzan, S. S., Hassan, N. A. I. F., Yaqout, Y. E., Tokunaga, A., Anozie, C., ElKoumi, O., Elawady, S. S., Mady, T., Nizam, S. N., Etman, Y., Nizam, R., Hazimeh, Y., Alazmy, M., & Aiash, H. (2024). Intestinal microbiome as a diagnostic marker of coronary artery disease: a systematic review and meta-analysis. Annals of medicine and surgery (2012), 86(10), 6105–6120. https://doi.org/10.1097/MS9.0000000000002516
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Annals of medicine and surgery
DOI
10.1097/MS9.0000000000002516
Academic Level
resident
Mentor/PI Department
Internal Medicine
Comments
Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.
This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/