School of Medicine Publications and Presentations
Document Type
Article
Publication Date
6-2025
Abstract
Background
Obesity paradox in post-percutaneous coronary intervention (PCI) outcomes among acute myocardial infarction (AMI) patients is a known controversy. However, these studies included patients who had diabetes, hypertension, or hyperlipidemia. We studied relationship between metabolically healthy obesity (MHO—without diabetes, hypertension, or hyperlipidemia) and in-hospital post-PCI outcomes among AMI patients.
Methods
We extracted data from National Inpatient Sample 2020 using International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes for admissions of AMI patients who underwent PCI. We then identified patients with diabetes, hypertension, and hyperlipidemia using Elixhauser comorbidity index and Clinical Classifications Software and excluded them. Then, using Elixhauser comorbidity index, we identified patients with and without obesity, defined as BMI > 30 kg/m2 and propensity score matching was done for age and sex. Later, multivariable regression analysis was done for in-hospital post-PCI outcomes.
Results
Among 25605 metabolically healthy patients who had AMI and underwent PCI, 2825 had obesity, and 22780 didn't. After propensity score matching (PSM) for age and sex, both cohorts had 2795 patients each. There was no statistically significant difference in in-hospital all-cause mortality (adjusted odds ratio [OR] 1.14, 95 % confidence interval [CI] 0.63–2.10, p = 0.661), post-PCI stroke (aOR 1.17, 95 % CI 0.50–2.75, p = 0.714), acute kidney injury (aOR 1.20, 95 % CI 0.84–1.72, p = 0.322), post-PCI bleeding (aOR 1.04, 95 % CI 0.35 to 3.12, p = 0.940) and intra or post-PCI cardiac arrest (aOR 1.14, 95 % CI 0.30 to 4.42, p = 0.835) between both cohorts.
Conclusions
No statistically significant association was found between obesity and post-PCI outcomes in metabolically healthy patients with AMI. Larger studies are needed to explore the controversial “obesity paradox” in cardiovascular diseases.
Recommended Citation
Desai, R., Pingili, A., Mahadevan, A., Bejugam, V. R., Ahmed, H., Borra, V., ... & Paul, T. (2025). Impact of Metabolically Healthy Obesity on Post Percutaneous Coronary Intervention Outcomes in Patients with Acute Myocardial Infarction: A Nationwide Propensity Matched Analysis. Obesity Pillars, 100167. https://doi.org/10.1016/j.obpill.2025.100167
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Publication Title
Obesity Pillars
DOI
10.1016/j.obpill.2025.100167
Academic Level
resident
Mentor/PI Department
Medical Education
Comments
© 2025 Published by Elsevier Inc. on behalf of Obesity Medicine Association. Under http://creativecommons.org/licenses/by-nc-nd/4.0/ license.