Title

Predictors of Outcome in Patients With Fibrolamellar Carcinoma: Analysis of the National Cancer Database

Document Type

Article

Publication Date

2-2020

Abstract

Background: Fibrolamellar carcinoma (FLC) is a very rare liver tumor. We aimed to retrospectively analyze the clinicopathological factors and treatment modalities affecting overall survival (OS) in FLC. The objective of the study was to identify predictors of survival in FLC.

Patients and methods: Using the National Cancer Database, we identified 496 patients diagnosed with FLC between 2004 and 2015. Clinicopathological, treatment, and survival data were collected.

Results: Hepatic resection was performed on 254 (51.2%) patients, liver-directed therapy on 13 (2.6%) patients, and liver transplantation on 15 (3.0%) patients. Median OS by stage were 142.1, 87.2, 32.3, and 14.1 months for stages 1, 2, 3, and 4, respectively. Metastatectomy was not associated with superior median OS (23.4 vs. 10.5 months, p=0.163). Age ≤40, low Charlson-Deyo comorbidity score, early stage and hepatic resection were independently associated with longer OS.

Conclusion: Our study reports current trends in FLC management, and identifies independent predictors of OS.

Comments

© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

First Page

847

Last Page

855

Publication Title

Anticancer Research

DOI

10.21873/anticanres.14017

Academic Level

faculty

Mentor/PI Department

Population Health and Biostatistics

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