School of Medicine Publications and Presentations

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Since the publication of our previous paper, Visual cycle proteins: Structure, function, and roles in human retinal disease (Tsin,, JBC 293:13016, 2018) there has been significant progress on multiple topics discussed in this paper. In the present communication, we further explore research advances on two visual cycle proteins: DES1 and IRBP. In addition, we emphasize the progress of clinical translation of other visual cycle protein research, including the breakthrough of FDA-approved gene therapy for Leber’s congenital amaurosis, and additional gene therapies at different stages of clinical trials for various retinal diseases such as retinitis pigmentosa, diabetic retinopathy, and Stargardt’s disease.


© 2020 Ooi XY, et al.

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Title

Archives of Clinical and Experimental Ophthalmology



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Mentor/PI Department

Molecular Science

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Ophthalmology Commons



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