Recent advances on visual cycle protein research and progress on clinical translation

Authors

Xin Yee Ooi, The University of Texas Rio Grande Valley
Rujman Khan, The University of Texas Rio Grande Valley
Anjalee Choudhury, The University of Texas Rio Grande Valley
Francisco Xavier Elisarraras, The University of Texas Rio Grande Valley
Jeff Grigsby
Brandi Obregon, The University of Texas Rio Grande Valley
Andrew T C Tsin, The University of Texas Rio Grande ValleyFollow

Document Type

Article

Publication Date

2020

Abstract

Since the publication of our previous paper, Visual cycle proteins: Structure, function, and roles in human retinal disease (Tsin, et.al, JBC 293:13016, 2018) there has been significant progress on multiple topics discussed in this paper. In the present communication, we further explore research advances on two visual cycle proteins: DES1 and IRBP. In addition, we emphasize the progress of clinical translation of other visual cycle protein research, including the breakthrough of FDA-approved gene therapy for Leber’s congenital amaurosis, and additional gene therapies at different stages of clinical trials for various retinal diseases such as retinitis pigmentosa, diabetic retinopathy, and Stargardt’s disease.

Comments

© 2020 Ooi XY, et al.

Recommended Citation

Ooi XY, Khan R, Choudhury A, Elisarraras FX, Grigsby J, Obregon B, et al. Recent advances on visual cycle protein research and progress on clinical translation. Arch Clin Exp Ophthalmol 2020; 2(3):73-76. doi.org/10.46439/ophthalmology.2.017

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Publication Title

Archives of Clinical and Experimental Ophthalmology

DOI

10.46439/ophthalmology.2.017

Academic Level

faculty

Mentor/PI Department

Molecular Science