Document Type

Article

Publication Date

1994

Abstract

The epsilon 4 isoform of apolipoprotein E (Apo-E) may confer genetic susceptibility for familial and sporadic Alzheimer's disease (AD). Because dementia in AD and Parkinson's disease (PD) share many biologic and clinical features, we determined the Apo-E genotypes for 79 patients with PD, 22 of whom were demented, and for 44 age-matched healthy elderly controls from the same community. We hypothesized that if the dementia was similar to AD, there would be a higher allele frequency of apolipoprotein epsilon 4 (Apo epsilon 4) in demented PD patients compared with nondemented PD patients and controls. The epsilon 4 allele frequency for PD without dementia was 0.132, for PD with dementia, 0.068, and for controls, 0.102. There was no association between Apo epsilon 4 and dementia in the PD patients. We conclude that the biologic basis for dementia in PD may differ from that of AD.

Comments

© 1994 by the American Academy of Neurology. Original published version available at https://doi.org/10.1212/WNL.44.7.1330

First Page

1330

Last Page

1331

Publication Title

Neurology

DOI

10.1212/wnl.44.7.1330

Academic Level

faculty

Mentor/PI Department

Neuroscience

Included in

Diseases Commons

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