School of Medicine Publications and Presentations
Document Type
Article
Publication Date
11-30-2021
Abstract
The development of fluorescence dyes for near‐infrared (NIR) fluorescence imaging has been a significant interest for deep tissue imaging. Among many imaging fluoroprobes, indocyanine green (ICG) and its analogues have been used in oncology and other medical applications. However, these imaging agents still experience poor imaging capabilities due to low tumor targetability, photostability, and sensitivity in the biological milieu. Thus, developing a biocompatible NIR imaging dye from natural resources holds the potential of facilitating cancer cell/tissue imaging. Chlorophyll (Chl) has been demonstrated to be a potential candidate for imaging purposes due to its natural NIR absorption qualities and its wide availability in plants and green vegetables. Therefore, it was our aim to assess the fluorescence characteristics of twelve dietary leaves as well as the fluorescence of their Chl extractions. Bay leaf extract, a high‐fluorescence agent that showed the highest levels of fluorescence, was further evaluated for its tissue contrast and cellular imaging properties. Overall, this study confirms bay‐leaf‐associated dye as a NIR fluorescence imaging agent that may have important implications for cellular imaging and image‐guided cancer surgery.
Recommended Citation
Adriano, B.; Cotto, N.M.; Chauhan, N.; Karumuru, V.; Jaggi, M.; Chauhan, S.C.; Yallapu, M.M. Bay Leaf Extract‐Based Near‐Infrared Fluorescent Probe for Tissue and Cellular Imaging. J. Imaging 2021, 7, 256. https://doi.org/10.3390/jimaging7120256
Creative Commons License
This work is licensed under a Creative Commons Attribution-Share Alike 4.0 International License.
Publication Title
Journal of Imaging
DOI
10.3390/jimaging7120256
Academic Level
faculty
Mentor/PI Department
Immunology and Microbiology
Comments
© 2021 by the authors.