Objectives: To find the predictive value of apolipoprotein E (apo E) and ambulatory measure of blood pressure in adolescents.
Methods: We performed ambulatory monitoring of blood pres- sure (AMBP) in 176 adolescents (13.18 years old) of both genders who came to the Center of cardiovascular Disease at the University of Zulia (Venezuela). The average BP during wake, sleep and 24 hours as well as their variations, were regístered. Apo E gen was also determined by Polimerase chain and the diagnosis of the genotype was made on the gel photography according to the combination of bands of different sizes.
Results: The adolescents were subdivided in three groups according to the presence of the apo E aleles: Group E2 (carriers of 2/2 or 2/3); Group E3 (carriers of 3/3) and Group E4 (carriers of 2/4, 3/4 or 4/4). Also the sample was divided in three groups according to the BP measures in hypertensive, "white coat" hypertensive and normotensive. There was no statistically significant relation with the different apo 11 carriers.
Conclusion: In the group of adolescents studied by us, no association between the aleles of apo E and the BP was found. This finding differs from other countries.
Maestre, Gladys E., "[Apolipoprotein E polimorphisms and ambulatory blood pressure monitoring during 24 hours in adolescents" (2001). School of Medicine Publications and Presentations. 48.
Revista de Medicina Interna