School of Medicine Publications and Presentations

Reply to the letter ‘Effectiveness of COVID-19 vaccines against Omicron variant’

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Response or Comment

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This is about the Letter to the Editor entitled ‘Effectiveness of COVID-19 vaccines against Omicron variant’ [1] in response to the published review ‘A global picture: therapeutic perspectives for COVID-19’ [2]. Since the publication of the review, we submitted a commentary article entitled ‘Therapeutics to tackle Omicron outbreak’, which was recently accepted in Immunotherapy [3]. This commentary article covers various therapeutics required to manage the Omicron outbreak. Following the worldwide dissemination of the SARS-CoV-2 Omicron BA.2 lineage, various BA.2-related variations with mutations in the L452 residue of the spike protein, such as BA.2.9.1 and BA.2.13 (L452M), BA.2.12.1 (L452Q) and BA.2.11, BA.4 and BA.5 (L452R), appeared in several nations [4]. The World Health Organization (WHO) designated B.1.1.529 as a variant of concern and it was named the Omicron variant. Omicron is different, highly transmissible, and potent new variant of SARS-CoV-2 due to the high number of mutations. Omicron was first identified in South Africa in November 2021 [5].


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Mentor/PI Department

Immunology and Microbiology