School of Medicine Publications and Presentations
Document Type
Article
Publication Date
1-19-2022
Abstract
Respiratory infections are one of the top causes of death in the elderly population, displaying susceptibility factors with increasing age that are potentially amenable to interventions. We posit that with increasing age there are predictable tissue-specific changes that prevent the immune system from working effectively in the lung. This mini-review highlights recent evidence for altered local tissue environment factors as we age focusing on increased tissue oxidative stress with associated immune cell changes, likely driven by the byproducts of age-associated inflammatory disease. Potential intervention points are presented.
Recommended Citation
Torrelles, J. B., Restrepo, B. I., Bai, Y., Ross, C., Schlesinger, L. S., & Turner, J. (2022). The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections. Frontiers in aging, 3, 818700. https://doi.org/10.3389/fragi.2022.818700
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Frontiers in Aging
DOI
10.3389/fragi.2022.818700
Academic Level
faculty
Mentor/PI Department
Office of Human Genetics
Comments
© 2022 Torrelles, Restrepo, Bai, Ross, Schlesinger and Turner.