School of Medicine Publications and Presentations

Document Type

Article

Publication Date

9-24-2022

Abstract

UVB irradiation is well known for its impact in the development of skin cancer. However, low UVB irradiation plays protective role against various human diseases including cancer through its effect on tumor suppression. This article summarizes the key findings of the paper by Park et al., which describes a novel molecular mechanism of moderate UVB irradiation in suppressing the growth of melanoma and colorectal cancer. Key observations in this paper are that moderate UVB irradiation can enhance tumor immunity by 1) increased infiltration of CD4+ and CD8+ T cells, 2) increased infiltration of CD103+ conventional type 1 dendritic cells (cDC1), and 3) a significant decrease of M2 tumor associate macrophages (TAMs) into tumor. The authors further identified the role of Batf3 transcription factor in moderate UVB irradiation mediated anti-tumor immune response. Deletion of Batf3 transcription factor reversed the tumor suppressive effect with decreased CD103+ cDC1 cell infiltration. This pre-clinical study provides a very novel mechanistic insight of the utilization of moderate UVB irradiation for the management of melanoma and colorectal cancer. This study further provides the direction of new future research to explore moderate UVB irradiation in combination with checkpoint blockade antibodies to enhance immunotherapeutic response against various solid tumors.

Comments

"This is the peer reviewed version of the following article:

Hafeez, B. B., Alvarado, E. W., & Kim, D. J. (2022). Therapeutic Implications of UVB Irradiation in Cancer by Enhancing Anti-Tumor Immunity. Photochemistry and photobiology, 10.1111/php.13729. Advance online publication. https://doi.org/10.1111/php.13729

which has been published in final form at https://doi.org/10.1111/php.13729. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

Publication Title

Photochemistry and Photobiology

DOI

10.1111/php.13729

Academic Level

faculty

Mentor/PI Department

Immunology and Microbiology

Available for download on Sunday, September 24, 2023

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