Nanomaterials for prostate cancer therapy and their current clinical trial status.
Strategies for conjugating different biomolecules with nanomaterials.
Biofunctionalized nanosystems used for the detection of different prostate-specific biomarkers and direct visualization of tumor cells.
Biofunctionalized nanosystems used for the targeted delivery of drugs and biomacromolecules.
Design and synthesis of biomimetic nanomaterials especially exosomes and viral particle functionalized nanomaterials against prostate cancer.
Even with the advancement in the areas of cancer nanotechnology, prostate cancer still poses a major threat to men’s health. Nanomaterials and nanomaterial-derived theranostic systems have been explored for diagnosis, imaging, and therapy for different types of cancer still, for prostate cancer they have not delivered at full potential because of the limitations like in vivo biocompatibility, immune responses, precise targetability, and therapeutic outcome associated with the nanostructured system.
Aim of review
Functionalizing nanomaterials with different biomolecules and bioactive agents provides advantages like specificity towards cancerous tumors, improved circulation time, and modulation of the immune response leading to early diagnosis and targeted delivery of cargo at the site of action.
Key scientific concepts of review
In this review, we have emphasized the classification and comparison of various nanomaterials based on biofunctionalization strategy and source of biomolecules such that it can be used for possible translation in clinical settings and future developments. This review highlighted the opportunities for embedding highly specific biological targeting moieties (antibody, aptamer, oligonucleotides, biopolymer, peptides, etc.) on nanoparticles which can improve the detection of prostate cancer-associated biomarkers at a very low limit of detection, direct visualization of prostate tumors and lastly for its therapy. Lastly, special emphasis was given to biomimetic nanomaterials which include functionalization with extracellular vesicles, exosomes and viral particles and their application for prostate cancer early detection and drug delivery. The present review paves a new pathway for next-generation biofunctionalized nanomaterials for prostate cancer theranostic application and their possibility in clinical translation.
Laskar, P., Jaggi, M., Chauhan, S. C., & Yallapu, M. M. (2023). Biomolecule-functionalized nanoformulations for prostate cancer theranostics. Journal of Advanced Research, 51, 197-217. https://doi.org/10.1016/j.jare.2022.11.001
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Journal of Advanced Research
Immunology and Microbiology