School of Medicine Publications and Presentations
Contribution of Inbred Singletons to Variance Component Estimation of Heritability and Linkage
An interesting consequence of consanguinity is that the inbred singleton becomes informative for genetic variance. We determine the contribution of an inbred singleton to variance component analysis of heritability and linkage.
Statistical theory for the power of variance component analysis of quantitative traits is used to determine the expected contribution of an inbred singleton to likelihood-ratio tests of heritability and linkage.
In variance component models an inbred singleton contributes relatively little to a test of heritability, but can contribute substantively to a test of linkage. For small to moderate QTL effects and a level of inbreeding comparable to matings between first cousins (the preferred form of union in many human populations), an inbred singleton can carry nearly 25% the information of a non-inbred sibpair. In more highly inbred contexts available with experimental animal populations, nonhuman primate colonies, and some human subpopulations, the contribution of an inbred singleton relative to a sibpair can exceed 50%.
Inbred individuals, even in isolation from other members of a sample, can contribute to variance component estimation and tests of heritability and linkage. Under certain conditions the informativeness of the inbred singleton can approach that of non-inbred sibpair.
Blondell, L., Blackburn, A., Kos, M. Z., Blangero, J., & Göring, H. H. H. (2018). Contribution of Inbred Singletons to Variance Component Estimation of Heritability and Linkage. Human heredity, 83(2), 92–99. https://doi.org/10.1159/000492830
Office of Human Genetics
Original published version available at https://doi.org/10.1159/000492830