The purpose of this study is to investigate and determine the role of PEDF in the pathogenesis of diabetic retinopathy as induced by advanced glycation end-products (AGEs). Human retinal pericytes were isolated from donors and will be measured for cell proliferation under the influence of PEDF both in the presence and absence of AGEs. Expected outcomes involve both the maintenance and increased survival of HRPs after treatment with PEDF under stimulated hyperglycemic conditions.
Choudhury, Anjalee; Tsin, Andrew; Perez, Zachary; and Elisarraras, Fransisco, "Observing growth effects of pigment epithelium-derived factor on human retinal pericytes in vitro" (2019). School of Medicine Publications and Presentations. 94.