Posters
Presenting Author Academic/Professional Position
Medical Student
Academic Level (Author 1)
Medical Student
Academic Level (Author 2)
Medical Student
Academic Level (Author 3)
Faculty
Discipline/Specialty (Author 3)
Medical Education
Presentation Type
Poster
Discipline Track
Clinical Science
Abstract Type
Research/Clinical
Abstract
Cutaneous T-cell lymphoma (CTCL) is a rare type of non-Hodgkin lymphoma primarily affecting the skin, with subtypes including mycosis fungoides and Sézary syndrome. This systematic review and meta-analysis aim to compare the efficacy of radiation therapy (e.g., total skin electron beam therapy, localized radiation) versus non-radiation treatments (e.g., chemotherapy, immunotherapy) in adults with CTCL. Comprehensive searches were conducted in databases such as PubMed, Cochrane Library, Web of Science, ScienceDirect, Ovid MEDLINE, ClinicalTrials.gov, and EU Clinical Trials Registry, focusing on studies published in English within the last five years. Primary outcomes include response rate, disease-free survival, overall survival, and quality of life, while secondary outcomes will include treatment toxicity and symptom relief. Two independent reviewers performed data extraction and risk of bias assessments. Meta-analyses are conducted using random-effects models to account for clinical and methodological diversity. Subgroup analyses are performed based on CTCL subtype, disease stage, and treatment modality. This review elucidates differences in response rates, disease control, and impacts on quality-of-life measures between radiation and non-radiation treatments for CTCL. Our findings highlight the need for personalized treatment strategies to optimize patient outcomes in managing CTCL.
Recommended Citation
Alanis, Anthony; Punch, Kory; and Zuo, Alex, "Comparing Radiation Therapy to Non-Radiation Treatments for Cutaneous T-Cell Lymphoma: A Systematic Review and Meta-Analysis" (2025). Research Symposium. 105.
https://scholarworks.utrgv.edu/somrs/2025/posters/105
Included in
Comparing Radiation Therapy to Non-Radiation Treatments for Cutaneous T-Cell Lymphoma: A Systematic Review and Meta-Analysis
Cutaneous T-cell lymphoma (CTCL) is a rare type of non-Hodgkin lymphoma primarily affecting the skin, with subtypes including mycosis fungoides and Sézary syndrome. This systematic review and meta-analysis aim to compare the efficacy of radiation therapy (e.g., total skin electron beam therapy, localized radiation) versus non-radiation treatments (e.g., chemotherapy, immunotherapy) in adults with CTCL. Comprehensive searches were conducted in databases such as PubMed, Cochrane Library, Web of Science, ScienceDirect, Ovid MEDLINE, ClinicalTrials.gov, and EU Clinical Trials Registry, focusing on studies published in English within the last five years. Primary outcomes include response rate, disease-free survival, overall survival, and quality of life, while secondary outcomes will include treatment toxicity and symptom relief. Two independent reviewers performed data extraction and risk of bias assessments. Meta-analyses are conducted using random-effects models to account for clinical and methodological diversity. Subgroup analyses are performed based on CTCL subtype, disease stage, and treatment modality. This review elucidates differences in response rates, disease control, and impacts on quality-of-life measures between radiation and non-radiation treatments for CTCL. Our findings highlight the need for personalized treatment strategies to optimize patient outcomes in managing CTCL.
