Posters
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Post-doc
Academic Level (Author 1)
Post-doc
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Immunology and Microbiology
Academic Level (Author 2)
Post-doc
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Immunology and Microbiology
Academic Level (Author 3)
Post-doc
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Immunology and Microbiology
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Family Medicine
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Faculty
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Immunology and Microbiology
Presentation Type
Poster
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Biomedical Science
Abstract Type
Research/Clinical
Abstract
Background: Electrospinning is a commonly employed method in tissue engineering due to its ability to produce nano-/microscale fibrous materials with mechanical and functional properties that mimic the extracellular matrix of living tissues. The general interest in electrospun fibrous matrices has recently expanded to cancer research both as scaffolds for in vitro cancer modeling and as patches for in vivo therapeutic delivery. This research aims to investigate the efficient delivery of anticancer drug in lung cancer treatment.
Methods: Three different biocompatible polymeric nanofibers (i.e. PCL fibers, PCL-PLGA mixed fibers, and PCL-PLGA tetra-layered fibers) loaded with docetaxel, were prepared using electrospinning technique. Size and morphology of developed fibers were assessed using a scanning electron microscope. The physico-chemical characterization of nanofibers was evaluated spectral, thermal, chromatography, crystallography methods. Various biological functional assays were employed to examine hemocompatibility, cellular binding and uptake, cytotoxicity of nanofibers.
Results: The surface morphology of prepared nanofibers revealed the formation of fibers i.e., smooth, porous, and rough surface topography. The formation of PCL and layer by layer (PCL and PLGA) fibers appeared to be bundled while mixing fibers (PCL and PLGA) are highly uniform and relatively smaller fibers. Its composition, docetaxel loading and release profiles are suitable for therapeutic applications. The nanofibers exhibit hemocompatibility and anti-thrombogenic properties. All three docetaxel loaded nanofibers demonstrated maximum cytotoxicity compared to free nanofibers.
Conclusions: These results indicate that the use of docetaxel loaded mixed nanofibers represents a promising alternative for the treatment of lung cancer. Further research is needed to explore its in vivo and future clinical translation.
Recommended Citation
Tiwari, Rahul; Pranav, Fnu; Hanuma Kumar Ghali, Eswara N.; Chauhan, Subhash; Yallapu, Murali; and Chavez, Luis, "Fabrication of docetaxel loaded PCL/PLGA electrospun nanofibers for lung cancer therapy" (2025). Research Symposium. 131.
https://scholarworks.utrgv.edu/somrs/2025/posters/131
Fabrication of docetaxel loaded PCL/PLGA electrospun nanofibers for lung cancer therapy
Background: Electrospinning is a commonly employed method in tissue engineering due to its ability to produce nano-/microscale fibrous materials with mechanical and functional properties that mimic the extracellular matrix of living tissues. The general interest in electrospun fibrous matrices has recently expanded to cancer research both as scaffolds for in vitro cancer modeling and as patches for in vivo therapeutic delivery. This research aims to investigate the efficient delivery of anticancer drug in lung cancer treatment.
Methods: Three different biocompatible polymeric nanofibers (i.e. PCL fibers, PCL-PLGA mixed fibers, and PCL-PLGA tetra-layered fibers) loaded with docetaxel, were prepared using electrospinning technique. Size and morphology of developed fibers were assessed using a scanning electron microscope. The physico-chemical characterization of nanofibers was evaluated spectral, thermal, chromatography, crystallography methods. Various biological functional assays were employed to examine hemocompatibility, cellular binding and uptake, cytotoxicity of nanofibers.
Results: The surface morphology of prepared nanofibers revealed the formation of fibers i.e., smooth, porous, and rough surface topography. The formation of PCL and layer by layer (PCL and PLGA) fibers appeared to be bundled while mixing fibers (PCL and PLGA) are highly uniform and relatively smaller fibers. Its composition, docetaxel loading and release profiles are suitable for therapeutic applications. The nanofibers exhibit hemocompatibility and anti-thrombogenic properties. All three docetaxel loaded nanofibers demonstrated maximum cytotoxicity compared to free nanofibers.
Conclusions: These results indicate that the use of docetaxel loaded mixed nanofibers represents a promising alternative for the treatment of lung cancer. Further research is needed to explore its in vivo and future clinical translation.
