Posters
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Medical Student
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Medical Student
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Medical Student
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Medical Student
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Faculty
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Orthopedic Surgery
Presentation Type
Poster
Discipline Track
Clinical Science
Abstract Type
Research/Clinical
Abstract
Background: Bone morphogenic proteins (BMPs) are critical in maintaining the homeostasis between osteoclasts and osteoblasts. With novel technology, BMPs have been increasingly successful in treating nonunion fractures. BMPs demonstrate promising results over other treatments such as bone grafting because it prevents complications like donor site morbidity, and limited grafting availability. This systematic review aims to evaluate the time of union, rate of success, and complications between BMP-2 and BMP-7 in upper and lower extremity non union fractures.
Methods: This systematic review was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA). Three databases were utilized: PubMed, Sage Journals, and CINHL using the Boolean operators - (((BMP) AND (nonunion)) AND (fracture)). The initial search yielded 466 articles and after implementation of exclusion and inclusion criteria and removing duplicates, 23 articles were used.
Results: A total of 285 patients were treated for nonunion fractures of bones such as the humerus, radius, ulna, femur, tibia and fibula. 50 patients were treated with BMP-2 and 235 patients were treated with BMP-7. In patients that were treated with BMP-2 had a time to union that ranged between 3-7 months, and a union rate ranging between 75-100%. Minimal complications were observed in two cases demonstrating rare inflammatory responses and soft tissue calcification. Patients that were treated with BMP-7 had a time of union that ranges between 4.5-8 months and an average union rate between 75-92%. Rare complications of BMP-7 included swelling, bruising, and one case of heterotopic ossification.
Conclusion: BMP-7 and BMP-2 demonstrate promising results for the treatment of nonunion fractures in the upper and lower extremity. While both types of treatments demonstrate efficacy, BMP-2 has a shorter time to union and BMP-7 has been observed to be used in more complex cases. The use of BMP demonstrated beneficial results for patients experiencing non healing fractures.
Recommended Citation
Gutierrez, Yolanda V.; Sepulveda, Alyssa A.; Shaju, Ronald A.; Rivera, Joaquin S.; and Ahmad, Aamir MD, "Utilization of BMP-2 or BMP-7 for Nonunion Fractures of the Upper and Lower Extremity" (2025). Research Symposium. 179.
https://scholarworks.utrgv.edu/somrs/2025/posters/179
Included in
Utilization of BMP-2 or BMP-7 for Nonunion Fractures of the Upper and Lower Extremity
Background: Bone morphogenic proteins (BMPs) are critical in maintaining the homeostasis between osteoclasts and osteoblasts. With novel technology, BMPs have been increasingly successful in treating nonunion fractures. BMPs demonstrate promising results over other treatments such as bone grafting because it prevents complications like donor site morbidity, and limited grafting availability. This systematic review aims to evaluate the time of union, rate of success, and complications between BMP-2 and BMP-7 in upper and lower extremity non union fractures.
Methods: This systematic review was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA). Three databases were utilized: PubMed, Sage Journals, and CINHL using the Boolean operators - (((BMP) AND (nonunion)) AND (fracture)). The initial search yielded 466 articles and after implementation of exclusion and inclusion criteria and removing duplicates, 23 articles were used.
Results: A total of 285 patients were treated for nonunion fractures of bones such as the humerus, radius, ulna, femur, tibia and fibula. 50 patients were treated with BMP-2 and 235 patients were treated with BMP-7. In patients that were treated with BMP-2 had a time to union that ranged between 3-7 months, and a union rate ranging between 75-100%. Minimal complications were observed in two cases demonstrating rare inflammatory responses and soft tissue calcification. Patients that were treated with BMP-7 had a time of union that ranges between 4.5-8 months and an average union rate between 75-92%. Rare complications of BMP-7 included swelling, bruising, and one case of heterotopic ossification.
Conclusion: BMP-7 and BMP-2 demonstrate promising results for the treatment of nonunion fractures in the upper and lower extremity. While both types of treatments demonstrate efficacy, BMP-2 has a shorter time to union and BMP-7 has been observed to be used in more complex cases. The use of BMP demonstrated beneficial results for patients experiencing non healing fractures.
