Document Type
Article
Publication Date
3-5-2012
Abstract
The classical Hantzsch reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful 1,4-dihydropyridine derivatives. Bismuth nitrate pentahydrate under microwave irradiation is proven to act as a very efficient catalyst for a one-pot, three-component synthesis of 1,4-dihydropyridines in excellent yields from diverse amines/ammonium acetate, aldehydes and 1,3-dicarbonyl compounds within 1-3 min under solvent-free conditions. The present environmentally benign procedure for the synthesis of 1,4-dihydropyridines is suitable for library synthesis and it will find application in the synthesis of potent biologically active molecules. The excellent yield and extreme rapidity of the method is due to a concurrent effect of the catalyst and microwave irradiation.
Recommended Citation
Bandyopadhyay, D., Maldonado, S., & Banik, B. K. (2012). A Microwave-Assisted Bismuth Nitrate-Catalyzed Unique Route Toward 1,4-Dihydropyridines. Molecules, 17(3), 2643–2662. https://doi.org/10.3390/molecules17032643
First Page
2643
Last Page
2662
Publication Title
Molecules
DOI
10.3390/molecules17032643
Comments
© 2012 the authors. Published under Creative Commons Attribution License 4.0. Original published version available at http://doi.org/10.3390/molecules17032643