Document Type
Article
Publication Date
2012
Abstract
The conjugate addition of amines to conjugated alkenes (commonly known as aza-Michael reaction) constitutes a key step for the synthesis of various complex natural products, antibiotics, α-amino alcohols and chiral auxiliaries. Ultrasound-induced addition of several amines to α, β-unsaturated ketones, esters and nitriles has been carried out very efficiently in water as well as under solvent-free conditions. No catalysts or solid supports have been used in this method. Remarkable enhancement of reaction rate has been observed in water under ultrasound-induced method. This environmentally benign procedure has provided clean formation of the products with better selectivity.
Recommended Citation
Bandyopadhyay, D., Mukherjee, S., Turrubiartes, L. C., & Banik, B. K. (2012). Ultrasound-assisted aza-Michael reaction in water: A green procedure. Ultrasonics Sonochemistry, 19(4), 969–973. https://doi.org/10.1016/j.ultsonch.2011.11.009
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
First Page
969
Last Page
973
Publication Title
Ultrasonics Sonochemistry
DOI
10.1016/j.ultsonch.2011.11.009
Comments
© 2011 Published by Elsevier B.V.