Association Study of Candidate Gene Polymorphisms and Obesity in a Young Mexican-American Population from South Texas

Authors

Jorge Duran-Gonzalez
Ixiu Ortiz
Enrique Gonzales
Nicole Ruiz
Manti Ortiz
Arthur Gonzalez
Edna K. Sanchez
Eugenia Curet, The University of Texas Rio Grande Valley
Susan P. Fisher-Hoch, University of Texas Health at Houston
Anne R. Rentfro, University of Texas at Brownsville
Huiqi Qu
Saraswathy Nair, The University of Texas Rio Grande Valley

Document Type

Article

Publication Date

8-2011

Abstract

Background and Aims

Obesity is increasingly a health problem and a risk factor for diabetes in young Mexican-American populations. Genetic association studies in older, mostly non-Hispanic populations have reported that polymorphisms in the candidate genes HSD11B1, CRP, ADIPOQ, PPARG, ANKK1, ABCC8 and SERPINF1 are associated with obesity or diabetes. We analyzed the polymorphisms rs846910, rs1205, rs1501299, rs1801282, rs1800497, rs757110 and rs1136287in these candidate genes, for association with obesity and metabolic traits in a young Mexican-American population from south Texas.

Methods

Genotyping of the seven common SNPs were performed by allelic discrimination assays in 448 unrelated Mexican Americans (median age = 16 years) from south Texas. χ2 tests and regression analyses using additive models were used for genetic association analyses adjusting for covariates; p values were corrected for multiple testing by permutation analyses.

Results

rs1800497 (ANKK1) shows association with waist circumference (p = 0.009) and retains the association (p = 0.03) after permutation testing. Analysis of metabolic quantitative traits shows that rs846910 (HSD11B1) was associated with HOMA-IR (p = 0.04) and triglycerides (p = 0.03), and rs1205 (CRP) with HOMA-IR (p = 0.03) and fasting glucose levels (p = 0.007). However, the quantitative traits associations are not maintained after permutation analysis. None of the other SNPs in this study showed associations with obesity or metabolic traits in this young Mexican-American population.

Conclusions

We report a potential association between rs1800497 (linked to changes in brain dopamine receptor levels) and central obesity in a young Mexican-American population.

Recommended Citation

Duran-Gonzalez, J., Ortiz, I., Gonzales, E., Ruiz, N., Ortiz, M., Gonzalez, A., Sanchez, E. K., Curet, E., Fisher-Hoch, S., Rentfro, A., Qu, H., & Nair, S. (2011). Association study of candidate gene polymorphisms and obesity in a young Mexican-American population from South Texas. Archives of medical research, 42(6), 523–531. https://doi.org/10.1016/j.arcmed.2011.10.010

Publication Title

Archives of medical research

DOI

https://doi.org/10.1016/j.arcmed.2011.10.010