School of Medicine Publications and Presentations
Document Type
Article
Publication Date
2-2024
Abstract
Snake venom is a rich source of bioactive molecules that hold great promise for therapeutic applications. These molecules can be broadly classified into enzymes and non-enzymes, each showcasing unique medicinal properties. Noteworthy compounds such as Bradykinin Potentiating Peptides (BPP) and Three-Finger Toxins (3FTx) are showing therapeutic potential in areas like cardiovascular diseases (CVDs) and pain-relief. Meanwhile, components like snake venom metalloproteinases (SVMP), L-amino acid oxidases (LAAO), and Phospholipase A2s (PLA2) are paving new ways in oncology treatments. The full medicinal scope of these toxins is still emerging. In this review, we discuss drugs derived from snake venoms that address CVDs, cancer, diabetes, strokes, and pain. Further, we outline the toxin distribution across 130 snake species, categorized by their genus within the Crotalidae, Viperidae, and Elapidae families. Conclusively, we spotlight the potential of Deep Learning (DL) in discovering groundbreaking drug prospects from these toxins.
Recommended Citation
Bedraoui, A., Suntravat, M., El Mejjad, S., Enezari, S., Oukkache, N., Sanchez, E. E., ... & Daouda, T. (2023). Therapeutic Potential of Snake Venom: Toxin Distribution and Opportunities in Deep Learning for Novel Drug Discovery. Medicine in Drug Discovery, 100175. https://doi.org/10.1016/j.medidd.2023.100175
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Publication Title
Medicine in Drug Discovery
DOI
10.1016/j.medidd.2023.100175
Academic Level
faculty
Mentor/PI Department
Office of Human Genetics
Comments
Under a Creative Commons license