Inulin-based formulations as an emerging therapeutic strategy for cancer: A comprehensive review

Authors

Eswara Naga H K Ghali, The University of Texas Rio Grande Valley
Pranav, The University of Texas Rio Grande Valley
Subhash C. Chauhan, The University of Texas Rio Grande Valley
Murali M. Yallapu, The University of Texas Rio Grande ValleyFollow

Document Type

Article

Publication Date

2-2024

Abstract

Highlights

• Inulin is a naturally occurring prebiotic fiber with therapeutic roles.

• Inulin can act as an excellent carrier for drug delivery in cancer therapy.

• Inulin exhibits an improved therapeutic efficacy in its combination treatments.

• Inulin interventions activate phagocytosis and the TLR4 signaling pathway.

Abstract

Cancer stands as the second leading cause of death in the United States (US). Most chemotherapeutic agents exhibit severe adverse effects that are attributed to exposure of drugs to off-target tissues, posing a significant challenge in cancer therapy management. In recent years, inulin, a naturally occurring prebiotic fiber has gained substantial attention for its potential in cancer treatment owing to its multitudinous health values. Its distinctive structure, stability, and nutritional properties position it an effective adjuvant and carrier for drug delivery in cancer therapy. To address some of the above unmet clinical issues, this review summarizes the recent efforts towards the development of inulin-based nanomaterials and nanocomposites for healthcare applications with special emphasis on the multifunctional role of inulin in cancer therapy as a synergist, signaling molecule, immunomodulatory and anticarcinogenic molecule. Furthermore, the review provides a concise overview of ongoing clinical trials and observational studies associated with inulin-based therapy. In conclusion, the current review offers insights on the significant role of inulin interventions in exploring its potential as a therapeutic agent to treat cancer.

Comments

Original published version available at https://doi.org/10.1016/j.ijbiomac.2024.129216

Recommended Citation

Ghali, E. N. H. K., Pranav, Chauhan, S. C., & Yallapu, M. M. (2024). Inulin-based formulations as an emerging therapeutic strategy for cancer: A comprehensive review. International journal of biological macromolecules, 259(Pt 1), 129216. https://doi.org/10.1016/j.ijbiomac.2024.129216

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.

Publication Title

International Journal of Biological Macromolecules

DOI

10.1016/j.ijbiomac.2024.129216

Academic Level

faculty

Mentor/PI Department

Immunology and Microbiology