Posters
Presentation Type
Poster
Discipline Track
Community/Public Health
Abstract Type
Research/Clinical
Abstract
The trail making test part B (TMT-B) is used to evaluate executive functions in order to better understand the progression of Alzheimer’s disease (AD). The objective of this study is to better understand the association of apolipoprotein E epsilon 4 (APOE-ε4) genotypes on the TMT-B scores in those with Alzheimer’s disease, specifically in the Hispanic population. This study used data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). In total there were 482 participants with AD, 503 with cognitive normal (CN), 1,293 with MCI at baseline and a follow-up after four years. In this study the longitudinal effect of apolipoprotein E epsilon 4 (APOE-ε4) genotypes on the TMT-B scores in those with Alzheimer’s disease was found. The results of this study found that individuals with 1 or 2 APOE-ε4 alleles had significantly higher TMT-B scores, which correlates to poor cognitive function, compared to individuals without APOE-ε4 allele at baseline and four follow-up visits using the multivariable linear mixed model. In addition, African American and Hispanic populations had higher TMT-B scores compared to whites. In conclusion our study found that there is a correlation between APOE-ε4 and TMT-B scores as well as an association between race and TMT-B scores.
Academic/Professional Position
Undergraduate
Recommended Citation
Ozuna, Kaysie N.; Katithara, Annu; and Xu, Chun, "Racial Differences in the Effect of APOE-ε4 Genotypes on Trail Making Test Part B in Alzheimer’s disease" (2023). Research Symposium. 84.
https://scholarworks.utrgv.edu/somrs/theme1/posters/84
Racial Differences in the Effect of APOE-ε4 Genotypes on Trail Making Test Part B in Alzheimer’s disease
The trail making test part B (TMT-B) is used to evaluate executive functions in order to better understand the progression of Alzheimer’s disease (AD). The objective of this study is to better understand the association of apolipoprotein E epsilon 4 (APOE-ε4) genotypes on the TMT-B scores in those with Alzheimer’s disease, specifically in the Hispanic population. This study used data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). In total there were 482 participants with AD, 503 with cognitive normal (CN), 1,293 with MCI at baseline and a follow-up after four years. In this study the longitudinal effect of apolipoprotein E epsilon 4 (APOE-ε4) genotypes on the TMT-B scores in those with Alzheimer’s disease was found. The results of this study found that individuals with 1 or 2 APOE-ε4 alleles had significantly higher TMT-B scores, which correlates to poor cognitive function, compared to individuals without APOE-ε4 allele at baseline and four follow-up visits using the multivariable linear mixed model. In addition, African American and Hispanic populations had higher TMT-B scores compared to whites. In conclusion our study found that there is a correlation between APOE-ε4 and TMT-B scores as well as an association between race and TMT-B scores.