Posters
Racially disparate expression of SPANXB1 in triple negative breast cancer
Presentation Type
Poster
Discipline Track
Clinical Science
Abstract Type
Research/Clinical
Abstract
Background: African American (AA) women are diagnosed more frequently with the triple negative breast cancer(TNBC), have an early onset and frequent recurrence, leading to an higher mortality than Caucasian (American (CA) women. SPANXB1 belongs to the SPANX family of cancer testis antigens (CTAs) expressed exclusively in the testis. Its overexpression; however, has also been detected in melanoma, colon, lung, and ovarian carcinomas. Here, we assessed the expression of SPANXB1in TNBCs from AA and CA women.
Methods: SPANXB1 expression was examined by immunohistochemistry in FFPE tissues from 20 CA and 20 AATNBCs and 10 normal cases. Digital pathology system (Leica Bioscience) was employed to evaluate extent and intensity of the staining.SPANXB1 staining was compared between racial groups and correlated with various clinic pathological parameters.
Results: Normal breast tissues and surrounding stroma were negative for SPANXB1and its expression was only detected in cancer tissues. SPANXB1 staining was predominantly cytoplasmic with diffuse nuclear expression in some cases.SPANXB1 expression was slightly higher in AA compared to CATNBCs. A slight but non-significant overexpression of SPANXB1 was also recorded in AATNBC with positive lymph node status and family history of cancer compared to that in CATNBC .No significant association of SPANXB1with stage was observed. An appreciable level of SPANXB1 was detected inductal in situ carcinomas, adjacent to invasive cancer suggesting a role of SANXB1in early progression.
Conclusion: Exclusive abundance of SPANXB1 in TNBCs suggest its pathobiological and translational significance as a novel molecular target for biomarker and therapeutic development.
Academic/Professional Position
Faculty
Academic/Professional Position (Other)
PhD
Recommended Citation
Vikramdeo, Kunwar S.; Dasaraju, Sandhyarani; Carter, J. E.; Singh, Ajay P.; and Dasgupta, Santanu, "Racially disparate expression of SPANXB1 in triple negative breast cancer" (2023). Research Symposium. 118.
https://scholarworks.utrgv.edu/somrs/theme1/posters/118
Racially disparate expression of SPANXB1 in triple negative breast cancer
Background: African American (AA) women are diagnosed more frequently with the triple negative breast cancer(TNBC), have an early onset and frequent recurrence, leading to an higher mortality than Caucasian (American (CA) women. SPANXB1 belongs to the SPANX family of cancer testis antigens (CTAs) expressed exclusively in the testis. Its overexpression; however, has also been detected in melanoma, colon, lung, and ovarian carcinomas. Here, we assessed the expression of SPANXB1in TNBCs from AA and CA women.
Methods: SPANXB1 expression was examined by immunohistochemistry in FFPE tissues from 20 CA and 20 AATNBCs and 10 normal cases. Digital pathology system (Leica Bioscience) was employed to evaluate extent and intensity of the staining.SPANXB1 staining was compared between racial groups and correlated with various clinic pathological parameters.
Results: Normal breast tissues and surrounding stroma were negative for SPANXB1and its expression was only detected in cancer tissues. SPANXB1 staining was predominantly cytoplasmic with diffuse nuclear expression in some cases.SPANXB1 expression was slightly higher in AA compared to CATNBCs. A slight but non-significant overexpression of SPANXB1 was also recorded in AATNBC with positive lymph node status and family history of cancer compared to that in CATNBC .No significant association of SPANXB1with stage was observed. An appreciable level of SPANXB1 was detected inductal in situ carcinomas, adjacent to invasive cancer suggesting a role of SANXB1in early progression.
Conclusion: Exclusive abundance of SPANXB1 in TNBCs suggest its pathobiological and translational significance as a novel molecular target for biomarker and therapeutic development.