Document Type
Article
Publication Date
2017
Abstract
Cardiovascular disease remains one of the leading causes of death in the United States. It is estimated that 1 in every 3 American adults suffer from high blood pressure. Hypertension, a precursor to most cardiovascular diseases, continues to grow at an alarming rate and is seldom managed carefully. Attempts have been made to manage hypertension and reduce the morbidity and mortality of the cardiovascular organ through methods including diets, increased amount of exercise, and medications. Many commercial drugs have been derived from dihydropyridine due to its antihypertensive property. Dihydropyridine derivatives work by acting as calcium channel blockers blocking the intake of calcium ions into the vascular smooth muscle and, to a lesser extent, cardiac muscles. Dihydropyridine moiety is well-known in pharmacology as L-type calcium channel blockers, which is extremely important since it treats hypertension in people who suffer from it. It is also highly important to understand the antagonists of calcium in the arterial hypertension. A brief overview is presented in this mini-review.
Recommended Citation
Salazar T, Gonzalez A, Bandyopadhyay D (2017) Dihydropyridines as Calcium Channel Blockers: An Overview. J Anal Pharm Res 5(4): 00148. DOI: 10.15406/japlr.2017.05.00148
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Publication Title
Journal of Analytical & Pharmaceutical Research
DOI
10.15406/japlr.2017.05.00148
Comments
©2017 Salazar, et al .