Synthesis of alkylthio benzene derivatives via simultaneous diazotization and nucleophilic displacement

Authors

Abraham Alvarado, University of Florida
Juan d. Deleija, Baylor College of Medicine
Jose J. Gutierrez, The University of Texas Rio Grande Valley

Document Type

Article

Publication Date

10-30-2021

Abstract

Alkylthio benzene derivatives were effectively synthesized by simultaneous diazotization of aromatic amines and nucleophilic displacement. The method is fairly general and proceeds in moderate yields. Product yields were comparable regardless of steric hindrance of the thiol or of the functional group present in the starting material. The newly developed procedure allowed for the incorporation of a tertiary alkylthio group, which cannot be easily introduced otherwise. The products were characterized by 1H NMR and 13C NMR.

Comments

© 2021 The Author(s). Published by Elsevier B.V.

Recommended Citation

Alvarado, Abraham, Juan d Deleija, and Jose J. Gutierrez. "Synthesis of alkylthio benzene derivatives via simultaneous diazotization and nucleophilic displacement." Results in Chemistry 3 (2021): 100227. https://doi.org/10.1016/j.rechem.2021.100227

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.

Publication Title

Results in Chemistry

DOI

10.1016/j.rechem.2021.100227