Medicinal bismuth: Bismuth-organic frameworks as pharmaceutically privileged compounds

Authors

Shaila A. Shetu, The University of Texas Rio Grande Valley
Luis M. Sanchez-Palestino, The University of Texas Rio Grande Valley
Gildardo Rivera-Sanchez, Instituto Politecnico Nacional, Mexico
Debasish Bandyopadhyay, The University of Texas Rio Grande ValleyFollow

Document Type

Article

Publication Date

12-17-2022

Abstract

Historically organometallic compounds have been used to cure certain diseases with limited applications. Although bismuth belongs to the category of heavy metals, many of its derivatives have found applications in modern drug discovery research, mainly because of its low toxicity and higher bioavailability. Being an eco-friendly mild Lewis acid, compounds having bismuth as a central atom are capable of binding several proteins in humans and other species. Bismuth complexes demonstrated antibacterial potential in syphilis, diarrhea, gastritis, and colitis. Apart from antibacterial activities, bismuth compounds exhibited anticancer, antileishmanial, and some extent of antifungal and other medicinal properties. This article discusses major synthetic methods and pharmacological potentials of bismuth complexes exhibiting in vitro activity to significant clinical performance in a systematic and timely manner.

Comments

Original published version available at https://doi.org/10.1016/j.tet.2022.133117

Recommended Citation

Shetu, S. A., Sanchez-Palestino, L. M., Rivera, G., & Bandyopadhyay, D. (2022). Medicinal bismuth: Bismuth-organic frameworks as pharmaceutically privileged compounds. Tetrahedron, 133117. https://doi.org/10.1016/j.tet.2022.133117

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.

Publication Title

Tetrahedron

DOI

10.1016/j.tet.2022.133117