Document Type

Article

Publication Date

3-1-2012

Abstract

The classical Hantzsch reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful 1,4-dihydropyridine derivatives. Bismuth nitrate pentahydrate under microwave irradiation is proven to act as a very efficient catalyst for a one-pot, three-component synthesis of 1,4-dihydropyridines in excellent yields from diverse amines/ammonium acetate, aldehydes and 1,3-dicarbonyl compounds within 1-3 min under solvent-free conditions. The present environmentally benign procedure for the synthesis of 1,4-dihydropyridines is suitable for library synthesis and it will find application in the synthesis of potent biologically active molecules. The excellent yield and extreme rapidity of the method is due to a concurrent effect of the catalyst and microwave irradiation.

Comments

© 2012 the authors. Published under Creative Commons Attribution License 4.0. Original published version available at http://doi.org/10.3390/molecules17032643.

Bandyopadhyay, D., Maldonado, S., Banik, R. A Microwave-Assisted Bismuth Nitrate-Catalyzed Unique Route Toward 14-Dihydropyridines. Molecules 2012, vol. 17, 2643-2662.

First Page

2643

Last Page

2662

Publication Title

Molecules

DOI

10.3390/molecules17032643

Included in

Chemistry Commons

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