Document Type
Article
Publication Date
2-23-2010
Abstract
Because of their interesting biological properties various methods for the synthesis of substituted pyrroles are described in the literature. However, synthesis of pyrroles fused with a β-lactam ring has not been reported. Our group has demonstrated synthesis and biological evaluation of various β-lactams as anticancer agents. The anticancer activities of these compounds have prompted us to study the synthesis of pyrroles bound to the β-lactams. We have identified an expeditious synthetic method for the preparation of pyrroles fused with β-lactams by reacting 3-amino β-lactams with acetonylacetone in the presence of catalytic amounts (5 mol%) of molecular iodine at room temperature. It has also been discovered that the reaction gives products under domestic and automated microwave oven irradiation. To our knowledge, there are no other prior reports that describe the synthesis of pyrrole-substituted β-lactams.
Recommended Citation
Bandyopadhyay, D., Rivera, G., Salinas, I., Aguilar, H., & Banik, B. K. (2010). Remarkable Iodine-Catalyzed Synthesis of Novel Pyrrole- Bearing N-Polyaromatic β-Lactams. Molecules, 15(2), 1082–1088. https://doi.org/10.3390/molecules15021082
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.
First Page
1082
Last Page
1088
Publication Title
Molecules
DOI
10.3390/molecules15021082
Comments
© 2010 the authors. Published under Creative Commons Attribution License 4.0. Original published version available at http://doi.org/10.3390/molecules15021082