Document Type
Article
Publication Date
4-2019
Abstract
Phytochemicals are inevitable part of human civilization. It is impossible to say exactly when menfolk started to take plant portions to cure various diseases. Phytochemical investigation of diethyl ether and ethanol extracts of Magnolia grandiflora green seed cones has been carried out. Extraction, isolation, and identification of the phytochemicals were carried out. Structures were determined by various analytical methods including extensive nuclear magnetic resonance, gas chromatography‐ mass spectroscopy, and X‐ray crystallographic analyses. Structures of the three compounds viz. 5,5′‐diallyl‐[1,1′‐biphenyl]‐2,2′‐diol (I), 3′,5‐diallyl‐[1,1′‐biphenyl]‐2,4′‐ diol (II), and (3S,3aS,8S,9aS,10aR,10bS,E)‐8‐hydroxy‐3,6,9a‐trimethyl‐3a,4,5,8,9,9a, 10a,10b‐octahydrooxireno[2′,3′:9,10]cyclodeca[1,2‐b]furan‐2(3H)‐one (III) were confirmed by X‐ray crystallographic analysis. GS‐MS studies of the isolated oil, eluted with hexanes, revealed the presence of eight compounds including two highly bioprivileged molecules 5,5′‐diallyl‐2′‐methoxy‐[1,1′‐biphenyl]‐2‐ol (IV) and 1‐(4‐isopropylbenzyl)‐ 1,3‐dihydro‐2H‐benzo[d]imidazol‐2‐one (V). The druggability of the five compounds has also been determined by in silico studies. The isolated compounds and/or their semi‐synthetic products may find application in natural drug development research.
Recommended Citation
Garza, B., Echeverria, A., Gonzalez, F., Castillo, O., Eubanks, T., & Bandyopadhyay, D. (2019). Phytochemical investigation of Magnolia grandiflora green seed cones: Analytical and phytoceutical studies. Food Science & Nutrition, 7(5), 1761–1767. https://doi.org/10.1002/fsn3.1016
First Page
1761
Last Page
1767
Publication Title
Food Science & Nutrition
DOI
10.1002/fsn3.1016
Comments
© 2019 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. Original published version available at https://www.doi.org/10.1002/fsn3.1016