An expeditious green route toward 2-aryl-4- phenyl-1H-imidazoles

Authors

Debasish Bandyopadhyay, The University of Texas Rio Grande ValleyFollow
Lauren C. Smith
Daniel R. Garcia
Ram Naresh Yadav
Bimal K. Banik, The University of Texas Rio Grande Valley

Document Type

Article

Publication Date

9-20-2014

Abstract

Background: Azaheterocycles are an important class of compounds because of their highly potent medicinal activities, and the imidazole subcategory is of special interest in regard to drug discovery research.

Findings: An expeditious synthetic protocol of 2-aryl-4-phenyl-1H-imidazoles has been accomplished by reacting phenylglyoxal monohydrate, ammonium acetate, and aldehyde under sonication. Following this green approach a series of 2-aryl-4-phenyl-1H-imidazoles has been synthesized using diversely substituted aldehydes.

Conclusions: A rapid and simple synthetic procedure to synthesize diversely substituted 2-aryl-4-phenyl-1H-imidazoles has been reported. Other salient features of this protocol include milder conditions, atom-economy, easy extraction, and minimum wastes. The present procedure may find application in the synthesis of biologically active molecules.

Comments

© 2014 Bandyopadhyay et al.; licensee Springer. Original published version available at doi.org/10.1186/s13588-014-0009-7

Recommended Citation

Bandyopadhyay, D., Smith, L. C., Garcia, D. R., Yadav, R. N., & Banik, B. K. (2014). An expeditious green route toward 2-aryl-4-phenyl-1H-imidazoles. Organic and Medicinal Chemistry Letters, 4(1), 9. https://doi.org/10.1186/s13588-014-0009-7

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.

Publication Title

Organic and Medicinal Chemistry Letters

DOI

10.1186/s13588-014-0009-7