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Human Genetics
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Human Genetics
Discipline Track
Translational Science
Abstract
Knowledge of genetic and environmental (G x E) interaction effects on metabolic-associated fatty liver disease (MAFLD) is limited. The purpose of this study was to examine the impact of G x E interaction effects on MAFLD in Mexican Americans in the Rio Grande Valley (RGV). The environment examined was depression as measured by the Beck Depression Inventory-II (BDI-II). We examined potential G x E interaction in the phenotypic expression of MAFLD, including hepatic steatosis and hepatic fibrosis, using variance component models and likelihood-based statistical inference. Significant G x E interactions were identified for hepatic fibrosis x BDI-II. These findings provide evidence that genetic factors interact with depression to influence expression of hepatic fibrosis. A better understanding of these genetic interactions are necessary to develop strategies and interventions to reduce the bi-directional relationship of hepatic fibrosis and depression.
Presentation Type
Poster
Recommended Citation
Sheikh, Khalid; Diego, Vincent P.; Laston, Sandra L.; Manusov, Eron G.; Williams-Blangero, Sarah; and Blangero, John, "Gene by Environment interaction and metabolic-associated fatty liver disease in Mexican American patients with depression" (2023). Research Colloquium. 24.
https://scholarworks.utrgv.edu/colloquium/2022/posters/24
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Biochemical Phenomena, Metabolism, and Nutrition Commons, Disorders of Environmental Origin Commons, Medical Genetics Commons, Nutritional and Metabolic Diseases Commons
Gene by Environment interaction and metabolic-associated fatty liver disease in Mexican American patients with depression
Knowledge of genetic and environmental (G x E) interaction effects on metabolic-associated fatty liver disease (MAFLD) is limited. The purpose of this study was to examine the impact of G x E interaction effects on MAFLD in Mexican Americans in the Rio Grande Valley (RGV). The environment examined was depression as measured by the Beck Depression Inventory-II (BDI-II). We examined potential G x E interaction in the phenotypic expression of MAFLD, including hepatic steatosis and hepatic fibrosis, using variance component models and likelihood-based statistical inference. Significant G x E interactions were identified for hepatic fibrosis x BDI-II. These findings provide evidence that genetic factors interact with depression to influence expression of hepatic fibrosis. A better understanding of these genetic interactions are necessary to develop strategies and interventions to reduce the bi-directional relationship of hepatic fibrosis and depression.