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Academic Level (Author 1)

Medical Student

Discipline Track

Clinical Science

Abstract

Patients with gallbladder adenocarcinomas are rare but present with low five-year survival rates. However, there are patients that survive long after their diagnosis with late-stage gallbladder cancer. The objective of this clinical case report is to highlight factors which may have contributed to this patient’s current 15-year survival to provide further insight on the prognosis of aggressive gallbladder adenocarcinomas.

A 43-year-old woman presented to the clinic with back pain. She had an ultrasound which showed dilated bile ducts and a filling defect with endoscopic retrograde cholangiopancreatography. A gall bladder mass was found and biopsied. Biopsy concluded the mass to be a stage IIIB gallbladder adenocarcinoma (T2N1M0R0) in 2007. Subsequently, she had a cholecystectomy with the resection of segments 4 and 5 of the liver, a resection of the extrahepatic bile ducts and received adjuvant chemotherapy.

Literature cites after a cholecystectomy, lymphadenectomy, and resection of adjacent affected organs, 5-year-survival can still be as low as 5% for gallbladder adenocarcinomas. A few cases of gallbladder adenocarcinomas attribute long-term survival to a multidisciplinary treatment of resection, chemotherapy, and concurrent radiotherapy and low serum levels of CA 19-9 for those with nodal involvement. A study of 40 patients with T3 gallbladder adenocarcinomas showed favorable survival with low serum carcinoembryonic antigen and negative resection margins.

This case highlights the factors of long-term survival in patients with gallbladder adenocarcinoma that may provide value in prescribing an appropriate treatment and assessing the prognosis of these potentially fatal cancers.

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Poster

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Long-Term Survival after Stage IIIB Gallbladder Adenocarcinoma

Patients with gallbladder adenocarcinomas are rare but present with low five-year survival rates. However, there are patients that survive long after their diagnosis with late-stage gallbladder cancer. The objective of this clinical case report is to highlight factors which may have contributed to this patient’s current 15-year survival to provide further insight on the prognosis of aggressive gallbladder adenocarcinomas.

A 43-year-old woman presented to the clinic with back pain. She had an ultrasound which showed dilated bile ducts and a filling defect with endoscopic retrograde cholangiopancreatography. A gall bladder mass was found and biopsied. Biopsy concluded the mass to be a stage IIIB gallbladder adenocarcinoma (T2N1M0R0) in 2007. Subsequently, she had a cholecystectomy with the resection of segments 4 and 5 of the liver, a resection of the extrahepatic bile ducts and received adjuvant chemotherapy.

Literature cites after a cholecystectomy, lymphadenectomy, and resection of adjacent affected organs, 5-year-survival can still be as low as 5% for gallbladder adenocarcinomas. A few cases of gallbladder adenocarcinomas attribute long-term survival to a multidisciplinary treatment of resection, chemotherapy, and concurrent radiotherapy and low serum levels of CA 19-9 for those with nodal involvement. A study of 40 patients with T3 gallbladder adenocarcinomas showed favorable survival with low serum carcinoembryonic antigen and negative resection margins.

This case highlights the factors of long-term survival in patients with gallbladder adenocarcinoma that may provide value in prescribing an appropriate treatment and assessing the prognosis of these potentially fatal cancers.

 

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