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Clinical Science

Abstract

Patients with gallbladder adenocarcinomas are rare but present with low five-year survival rates. However, there are patients that survive long after their diagnosis with late-stage gallbladder cancer. The objective of this clinical case report is to highlight factors which may have contributed to this patient’s current 15-year survival to provide further insight on the prognosis of aggressive gallbladder adenocarcinomas.

A 43-year-old woman presented to the clinic with back pain. She had an ultrasound which showed dilated bile ducts and a filling defect with endoscopic retrograde cholangiopancreatography. A gall bladder mass was found and biopsied. Biopsy concluded the mass to be a stage IIIB gallbladder adenocarcinoma (T2N1M0R0) in 2007. Subsequently, she had a cholecystectomy with the resection of segments 4 and 5 of the liver, a resection of the extrahepatic bile ducts and received adjuvant chemotherapy.

Literature cites after a cholecystectomy, lymphadenectomy, and resection of adjacent affected organs, 5-year-survival can still be as low as 5% for gallbladder adenocarcinomas. A few cases of gallbladder adenocarcinomas attribute long-term survival to a multidisciplinary treatment of resection, chemotherapy, and concurrent radiotherapy and low serum levels of CA 19-9 for those with nodal involvement. A study of 40 patients with T3 gallbladder adenocarcinomas showed favorable survival with low serum carcinoembryonic antigen and negative resection margins.

This case highlights the factors of long-term survival in patients with gallbladder adenocarcinoma that may provide value in prescribing an appropriate treatment and assessing the prognosis of these potentially fatal cancers.

Presentation Type

Poster

Academic Level

Medical Student

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Long-Term Survival after Stage IIIB Gallbladder Adenocarcinoma

Patients with gallbladder adenocarcinomas are rare but present with low five-year survival rates. However, there are patients that survive long after their diagnosis with late-stage gallbladder cancer. The objective of this clinical case report is to highlight factors which may have contributed to this patient’s current 15-year survival to provide further insight on the prognosis of aggressive gallbladder adenocarcinomas.

A 43-year-old woman presented to the clinic with back pain. She had an ultrasound which showed dilated bile ducts and a filling defect with endoscopic retrograde cholangiopancreatography. A gall bladder mass was found and biopsied. Biopsy concluded the mass to be a stage IIIB gallbladder adenocarcinoma (T2N1M0R0) in 2007. Subsequently, she had a cholecystectomy with the resection of segments 4 and 5 of the liver, a resection of the extrahepatic bile ducts and received adjuvant chemotherapy.

Literature cites after a cholecystectomy, lymphadenectomy, and resection of adjacent affected organs, 5-year-survival can still be as low as 5% for gallbladder adenocarcinomas. A few cases of gallbladder adenocarcinomas attribute long-term survival to a multidisciplinary treatment of resection, chemotherapy, and concurrent radiotherapy and low serum levels of CA 19-9 for those with nodal involvement. A study of 40 patients with T3 gallbladder adenocarcinomas showed favorable survival with low serum carcinoembryonic antigen and negative resection margins.

This case highlights the factors of long-term survival in patients with gallbladder adenocarcinoma that may provide value in prescribing an appropriate treatment and assessing the prognosis of these potentially fatal cancers.

 

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