Posters
Academic Level (Author 1)
Medical Student
Discipline/Specialty (Author 1)
Orthopedic Surgery
Academic Level (Author 2)
Faculty
Discipline/Specialty (Author 2)
Family and Community Medicine
Discipline Track
Clinical Science
Abstract
Background: Prosthetic joint infection is a high cost and high morbidity complication of total joint arthroplasty accounting for about 1-2% of all joint replacements. Rarely fungal infections may complicate treatment and lower the rate of clearance of infection with rates as low as 50% or less in the literature. Intra-articular antibiotics have drawn more interest recently and may be a promising intervention for challenging prosthetic joint infections. We present a novel case utilizing voriconazole via intra-articular catheters with successful clearance of a recalcitrant fungal prosthetic joint infection with 2 year follow up.
Case Presentation: A case study is presented in which a recalcitrant fungal prosthetic joint infection is first treated via a single-stage both component knee revision with placement of 2 indwelling intra-articular catheters. Subsequently voriconazole was administered daily for 6 weeks in alternating catheters. After completion of antifungal treatment, the catheters were removed at bedside. Our patient was successfully treated with intra-articular voriconazole for 6 weeks. The patient demonstrates no evidence of infection after 2 years.
Conclusions: To our knowledge this is the first case in which intra-articular voriconazole is administered through indwelling catheters of the knee. We demonstrate successful clearance of a complex fungal prosthetic joint infection using this novel treatment. Intra-articular use of voriconazole may be an option for patients with fungal prosthetic joint infection.
Presentation Type
Poster
Recommended Citation
Martin, Blake; Hnatow, Matthew; and Herrera, Emma, "Clearance of Recalcitrant Prosthetic Fungal Infection Utilizing Administration of Voriconazole Through Intra-articular Catheters of the Knee" (2024). Research Colloquium. 65.
https://scholarworks.utrgv.edu/colloquium/2024/posters/65
Included in
Clearance of Recalcitrant Prosthetic Fungal Infection Utilizing Administration of Voriconazole Through Intra-articular Catheters of the Knee
Background: Prosthetic joint infection is a high cost and high morbidity complication of total joint arthroplasty accounting for about 1-2% of all joint replacements. Rarely fungal infections may complicate treatment and lower the rate of clearance of infection with rates as low as 50% or less in the literature. Intra-articular antibiotics have drawn more interest recently and may be a promising intervention for challenging prosthetic joint infections. We present a novel case utilizing voriconazole via intra-articular catheters with successful clearance of a recalcitrant fungal prosthetic joint infection with 2 year follow up.
Case Presentation: A case study is presented in which a recalcitrant fungal prosthetic joint infection is first treated via a single-stage both component knee revision with placement of 2 indwelling intra-articular catheters. Subsequently voriconazole was administered daily for 6 weeks in alternating catheters. After completion of antifungal treatment, the catheters were removed at bedside. Our patient was successfully treated with intra-articular voriconazole for 6 weeks. The patient demonstrates no evidence of infection after 2 years.
Conclusions: To our knowledge this is the first case in which intra-articular voriconazole is administered through indwelling catheters of the knee. We demonstrate successful clearance of a complex fungal prosthetic joint infection using this novel treatment. Intra-articular use of voriconazole may be an option for patients with fungal prosthetic joint infection.