Posters
Cardiovascular Response Patterns to Oral versus Transdermal Estrogen Therapy in Postmenopausal Women
Presenting Author Academic/Professional Position
Jose J Loayza Pintado / Resident Physician PGY2
Academic Level (Author 1)
Resident
Academic Level (Author 2)
Resident
Discipline/Specialty (Author 2)
Internal Medicine
Discipline Track
Clinical Science
Abstract Type
Research/Clinical
Abstract
Introduction: The comparative effects of oral versus transdermal estrogen therapy on cardiovascular parameters in postmenopausal women remain incompletely understood. This analysis aimed to evaluate blood pressure and heart rate responses between administration routes.
Methods: A systematic review of randomized trials comparing oral and transdermal estrogen therapy in postmenopausal women was conducted. Primary outcomes included changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate. Random-effects meta-analysis was performed to calculate pooled mean differences (MD) with 95% confidence intervals (CI).
Results: Analysis of 8 randomized trials (N=885) showed no significant differences between oral and transdermal routes in mean changes from baseline for SBP (MD=1.45 mmHg; 95% CI: -0.21 to 3.12; p=0.09) or DBP (MD=1.07 mmHg; 95% CI: -0.11 to 2.24; p=0.08). Heart rate changes were comparable between groups (MD=0.05; 95% CI: -1.43 to 1.52; p=0.95). Subgroup analysis by treatment duration (≤6 vs >6 months) revealed consistent blood pressure findings across follow-up periods.
Conclusions: Oral and transdermal estrogen demonstrate comparable effects on blood pressure and heart rate in postmenopausal women, suggesting both routes may be suitable from a cardiovascular perspective. These findings can help inform individualized treatment decisions regarding estrogen therapy administration route.
Presentation Type
Poster
Recommended Citation
Doma, Mohamed; Loayza Pintado, Jose J.; Atwal, Aria; Lopez Jesus, Angelica; Zahrawi, Farhaan; Saleh, Ibrahim; El Gammal, Ahmed; Maharm, Zeyad; Galal Ramadan, Adham; Vlassis, Benito; Shafeeq Ali, Mustafa; Khodr Aljamali, Mohammad; Pandey, Ralph; Mefti, Mounira; Badran, Merhan; Aslam, Muaaz; Subedi, Anuj; Shah, Jaffer; and Aiash, Hani, "Cardiovascular Response Patterns to Oral versus Transdermal Estrogen Therapy in Postmenopausal Women" (2026). Research Colloquium. 113.
https://scholarworks.utrgv.edu/colloquium/2025/posters/113
Included in
Cardiovascular Response Patterns to Oral versus Transdermal Estrogen Therapy in Postmenopausal Women
Introduction: The comparative effects of oral versus transdermal estrogen therapy on cardiovascular parameters in postmenopausal women remain incompletely understood. This analysis aimed to evaluate blood pressure and heart rate responses between administration routes.
Methods: A systematic review of randomized trials comparing oral and transdermal estrogen therapy in postmenopausal women was conducted. Primary outcomes included changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate. Random-effects meta-analysis was performed to calculate pooled mean differences (MD) with 95% confidence intervals (CI).
Results: Analysis of 8 randomized trials (N=885) showed no significant differences between oral and transdermal routes in mean changes from baseline for SBP (MD=1.45 mmHg; 95% CI: -0.21 to 3.12; p=0.09) or DBP (MD=1.07 mmHg; 95% CI: -0.11 to 2.24; p=0.08). Heart rate changes were comparable between groups (MD=0.05; 95% CI: -1.43 to 1.52; p=0.95). Subgroup analysis by treatment duration (≤6 vs >6 months) revealed consistent blood pressure findings across follow-up periods.
Conclusions: Oral and transdermal estrogen demonstrate comparable effects on blood pressure and heart rate in postmenopausal women, suggesting both routes may be suitable from a cardiovascular perspective. These findings can help inform individualized treatment decisions regarding estrogen therapy administration route.
