Posters
Presenting Author Academic/Professional Position
Noah Al-Hassan
Academic Level (Author 1)
Graduate Student
Academic Level (Author 2)
Medical Student
Academic Level (Author 5)
Faculty
Discipline Track
Patient Care
Abstract Type
Research/Clinical
Abstract
Background: Non‐surgical periodontal therapy reduces bacterial biofilm and inflammation in chronic periodontitis but often leaves residual pockets. Vitamin D₃ has immunomodulatory and anti‐inflammatory effects that may improve healing when added. Randomized evidence in patients with type 2 diabetes mellitus (T2DM) is scarce.
Methods: We meta‐analyzed two RCTs from 2023–2024. Lei et al. randomized 60 non‐diabetic adults to high‐dose (100 000 IU/month), low‐dose (25 000 IU/month), or no vitamin D₃ with standard therapy. Ramaprabha et al. enrolled 92 males (46 with T2DM, 46 without) randomized to 60 000 IU/week vitamin D₃ or therapy alone. Outcomes were changes in probing pocket depth (PPD), clinical attachment level (CAL), gingival bleeding index (GBI), and serum 25-hydroxyvitamin D 25(OH)D. Random‐effects models estimated Hedges’ g and subgroup analyses compared results by diabetes status.
Results: Adjunctive vitamin D₃ significantly reduced PPD (g = –3.39) and CAL (g = –2.94), and decreased GBI (g = –1.80) (all p < 0.05). Serum 25(OH)D rose markedly (g = 7.67) with high heterogeneity (I² > 90%). Non-diabetics experienced greater PPD and CAL gains than participants with T2DM (p < 0.05); GBI response was similar across groups. Attenuated effects in T2DM may reflect altered vitamin D metabolism and chronic inflammation.
Conclusions: Adjunctive oral vitamin D₃ enhances periodontal outcomes, especially in non-diabetic patients. Future large RCTs should refine dosing protocols and assess efficacy in metabolically disregulated populations.
Presentation Type
Poster
Recommended Citation
Al-Hassan, Noah; Cauba, John Nicholas; Al-Hassan, Taha; Korrapati, Krishi; Guadarrama-Beltran, Seratna; Quinones, Maria; and Lopez-Alvarenga, Juan Carlos, "Vitamin D3 Improves Non-Surgical Periodontal Treatment Outcomes, with Reduced Benefit in Type 2 Diabetes: Evidence from Two Randomized Controlled Trials (RCT)" (2025). Research Colloquium. 80.
https://scholarworks.utrgv.edu/colloquium/2025/posters/80
Included in
Vitamin D3 Improves Non-Surgical Periodontal Treatment Outcomes, with Reduced Benefit in Type 2 Diabetes: Evidence from Two Randomized Controlled Trials (RCT)
Background: Non‐surgical periodontal therapy reduces bacterial biofilm and inflammation in chronic periodontitis but often leaves residual pockets. Vitamin D₃ has immunomodulatory and anti‐inflammatory effects that may improve healing when added. Randomized evidence in patients with type 2 diabetes mellitus (T2DM) is scarce.
Methods: We meta‐analyzed two RCTs from 2023–2024. Lei et al. randomized 60 non‐diabetic adults to high‐dose (100 000 IU/month), low‐dose (25 000 IU/month), or no vitamin D₃ with standard therapy. Ramaprabha et al. enrolled 92 males (46 with T2DM, 46 without) randomized to 60 000 IU/week vitamin D₃ or therapy alone. Outcomes were changes in probing pocket depth (PPD), clinical attachment level (CAL), gingival bleeding index (GBI), and serum 25-hydroxyvitamin D 25(OH)D. Random‐effects models estimated Hedges’ g and subgroup analyses compared results by diabetes status.
Results: Adjunctive vitamin D₃ significantly reduced PPD (g = –3.39) and CAL (g = –2.94), and decreased GBI (g = –1.80) (all p < 0.05). Serum 25(OH)D rose markedly (g = 7.67) with high heterogeneity (I² > 90%). Non-diabetics experienced greater PPD and CAL gains than participants with T2DM (p < 0.05); GBI response was similar across groups. Attenuated effects in T2DM may reflect altered vitamin D metabolism and chronic inflammation.
Conclusions: Adjunctive oral vitamin D₃ enhances periodontal outcomes, especially in non-diabetic patients. Future large RCTs should refine dosing protocols and assess efficacy in metabolically disregulated populations.
