Document Type
Conference Proceeding
Publication Date
10-4-2024
Abstract
The MRI-derived brain network serves as a pivotal instrument in elucidating both the structural and functional aspects of the brain, encompassing the ramifications of diseases and developmental processes. However, prevailing methodologies, often focusing on synchronous BOLD signals from functional MRI (fMRI), may not capture directional influences among brain regions and rarely tackle temporal functional dynamics. In this study, we first construct the brain-effective network via the dynamic causal model. Subsequently, we introduce an interpretable graph learning framework termed Spatio-Temporal Embedding ODE (STE-ODE). This framework incorporates specifically designed directed node embedding layers, aiming at capturing the dynamic inter-play between structural and effective networks via an ordinary differential equation (ODE) model, which characterizes spatial-temporal brain dynamics. Our framework is validated on several clinical phenotype prediction tasks using two independent publicly available datasets (HCP and OASIS). The experimental results clearly demonstrate the advantages of our model compared to several state-of-the-art methods.
Recommended Citation
Tang, Haoteng, Guodong Liu, Siyuan Dai, Kai Ye, Kun Zhao, Wenlu Wang, Carl Yang et al. "Interpretable Spatio-Temporal Embedding for Brain Structural-Effective Network with Ordinary Differential Equation." In International Conference on Medical Image Computing and Computer-Assisted Intervention, pp. 227-237. Cham: Springer Nature Switzerland, 2024. https://doi.org/10.1007/978-3-031-72069-7_22
Publication Title
International Conference on Medical Image Computing and Computer-Assisted Intervention
DOI
https://doi.org/10.1007/978-3-031-72069-7_22
