Electrical and Computer Engineering Faculty Publications and Presentations
Document Type
Conference Proceeding
Publication Date
5-2025
Abstract
Glucose is a crucial metabolic marker, providing critical insights into energy regulation and insulin sensitivity, making its monitoring essential for managing diabetes and overall metabolic health. In this context, flexible biosensors have gained considerable attention for their potential to enable real-time and non-invasive glucose monitoring. One promising advancement in this domain is using Zinc-Oxide (ZnO) nanostructures through sonochemical synthesis. ZnO has a wide bandgap of ∼3.37 eV and a large binding energy of 60 meV. This research focuses on ZnO-Nanowires' growth for the first time on a flexible polymer substrate. The average length and diameter of the nanowires are 2.5µm and 50 nm, resulting in a surface-to-volume ratio is approximately 0.08 nm⁻¹. This high ratio indicates a large surface area relative to the volume, which is crucial in enhancing the sensitivity of nanowires for biosensing applications. The ZnO-NWs' distinctive properties stem from their highly polarized (0001) plane orientation, which enhances enzyme immobilization and, consequently, the sensor's performance. ZnO-NWs’ high isoelectric point (9.5) facilitates the immobilization of biomolecules, such as enzymes, without any additional binding layer. The biosensor's design is based on the immobilization of Glucose Oxidase (Gox) on ZnO-NWs. This configuration results in a highly flexible sensor that maintains its performance across various mechanical deformations. The biosensor showed a clear, linear response to glucose concentrations ranging from 200 µM to 10 mM. Its sensitivity was measured at 8.918 µA/mM, and the response curve was significantly linear, with an R² value of about 98.07.
Recommended Citation
Hossain, GM Mehedi, Ahmed Jalal, Hasina Huq, Nazmul Islam, Karen Lozano, Nezih Pala, and Fahmida Alam. "Sonochemically synthesized ZnO nanowires (NWs)-based sensor for non-invasive glucose detection in sweat." In Smart Biomedical and Physiological Sensor Technology XXII, vol. 13481, pp. 38-44. SPIE, 2025. https://doi.org/10.1117/12.3053553
Publication Title
Proceedings Volume 13481, Smart Biomedical and Physiological Sensor Technology XXII
DOI
10.1117/12.3053553
Comments
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