Theses and Dissertations

Date of Award


Document Type


Degree Name

Master of Science (MS)


Biochemistry and Molecular Biology

First Advisor

Dr. Manish Tripathi

Second Advisor

Dr. Subhash Chauhan

Third Advisor

Dr. Meena Jaggi


Treatment options for cancer are becoming much more limited due to the robust characteristics of cancer that allows them to rapidly develop drug resistance. This may be a result of cancer cells’ ability to switch between differentiated and undifferentiated states (plasticity). Diagnostic measurement and detection of cancer and its progression is essential for developing successful treatments. Specific cancer targets whose expressions are highly associated with increased incidence, risk, and spread of cancer therefore become perfect targets for therapeutic intervention. One such novel target that is still being studied is the Y-box binding protein 1 (YB-1), which is a prominent transcription factor in many cancer types including breast, liver, and colorectal. Therefore, attacking these cancer targets with specific drugs that act against them may prove to be extremely helpful in fighting off its associated cancer. Taking advantage of the latest bioinformatics tools may aid in streamlining this process.


Copyright 2022 Omar Muneer Karkoutly. All Rights Reserved.