Date of Award
Master of Science (MS)
Dr. Megan Keniry
Dr. Robert Gilkerson
Dr. Michael Persans
Glioblastoma Multiforme (GBM) and basal-like breast cancer (BBC) are aggressive cancers associated with poor prognoses. Basal-like breast cancer (BBC) and glioblastoma multiforme (GBM) are poor prognosis cancers that lack effective targeted therapies. A deregulation of FOXOs has been linked to cancer, as they regulate the expression of genes involved in multiple cellular processes. Canonically, the FOXO family of proteins is generally considered tumor suppressors, but evidence suggests that they may be involved in cancer metabolism as well as angiogenesis. Research in our lab has found that these factors play a role in glycolysis and the developmental WNT pathway. Here we aim to uncover novel roles that these factors play by performing chromatin immunoprecipitation (ChIP) assays with sequencing. This research helped to identify thousands of novel FOXO transcription factor targets as well as the roles that may allow them to drive cancer.
Lopez, Alma, "Identifying Direct FOXO Targets Through Chromatin Immunoprecipitation Assays with Sequencing" (2023). Theses and Dissertations - UTRGV. 1271.
Available for download on Friday, July 25, 2025