Biocompatible microchannel scaffold with microwires for recording regenerative peripheral nerve neural spikes

Author

Manisankar Chennamsetti, The University of Texas Rio Grande Valley

Date of Award

8-2016

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Electrical Engineering

First Advisor

Dr. Yoonsu Choi

Second Advisor

Dr. Nazmul Islam

Third Advisor

Dr. Jaimes S. Ramos - Salas

Abstract

A new process for the fabrication of a microchannel scaffold with microwires for peripheral nerve applications is presented. This microchannel scaffold implemented between the ends of nerves, the axons of which regenerate through microchannel in scaffold and fixed microelectrodes. This device is entirely handcrafted using commercially available materials such as microwires, PDMS film, liquid PDMS, dental cement, and epoxy glue. This device was implemented in the a Lewis rat sciatic nerve to better analyze the electrical signals of regenerated axons. 64-electrode microchannel scaffolds were developed for both peripheral nerve interfacing and peripheral nerve regeneration. The microwires were used for recording electrode to capture neural signal from the regenerated peripheral nerves. To further differentiate the methodology, the new addition of a ribbon cable will facilitate the transmission of the electrical signals. A total of eight devices have been developed, the nerve regeneration were examined four weeks after device implantation.

Comments

Copyright 2016 Manisankar Chennamsetti. All Rights Reserved.

https://www.proquest.com/dissertations-theses/biocompatible-microchannel-scaffold-with/docview/1850204861/se-2?accountid=7119

Recommended Citation

Chennamsetti, Manisankar, "Biocompatible microchannel scaffold with microwires for recording regenerative peripheral nerve neural spikes" (2016). Theses and Dissertations. 135.
https://scholarworks.utrgv.edu/etd/135