Theses and Dissertations
Apoptotic and necrotizing mechanisms of recombinant Panton-Valentine leukocidin in THP1 monocytes.
Date of Award
Master of Science (MS)
Dr. Luis Materon
Dr. Anxiu Kuang
Dr. Robert Gilkerson
The Panton-Valentine Leukocidin (PVL) is a highly specialized bacterial exotoxin produced by Staphylococcus aureus. The increased degree of invasiveness of community associated methicillin resistant Staphylococcus aureus (CAMRSA) has been attributed to the relatively high rates of PVL produced by the pathogen, thus increasing pathogenicity and virulence. The increased rates of PVL encoding CAMRSA infections have been correlated with increased rates of necrotizing fasciitis, invasive osteomyelitis and invasive necrotizing pneumococcal infections. Previous research as revealed that PVL has the ability to induce apoptosis at low concentration (5nM-10nM) and necrosis (50-100nM) at high concentrations, with little detail on the mechanism of initiation. This research delineates concentrations dependent activation of programmed cell death as a factor of time, indicating a time dependent factor for inter-molecular communication between both mechanisms of cell death.
DeLeon, Heriberto III, "Apoptotic and necrotizing mechanisms of recombinant Panton-Valentine leukocidin in THP1 monocytes." (2016). Theses and Dissertations. 27.
Copyright 2016 Heriberto DeLeon III. All Rights Reserved.