Apoptotic and necrotizing mechanisms of recombinant Panton-Valentine leukocidin in THP1 monocytes.

Author

Heriberto DeLeon III, The University of Texas Rio Grande Valley

Date of Award

5-2016

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Biology

First Advisor

Dr. Luis Materon

Second Advisor

Dr. Anxiu Kuang

Third Advisor

Dr. Robert Gilkerson

Abstract

The Panton-Valentine Leukocidin (PVL) is a highly specialized bacterial exotoxin produced by Staphylococcus aureus. The increased degree of invasiveness of community associated methicillin resistant Staphylococcus aureus (CAMRSA) has been attributed to the relatively high rates of PVL produced by the pathogen, thus increasing pathogenicity and virulence. The increased rates of PVL encoding CAMRSA infections have been correlated with increased rates of necrotizing fasciitis, invasive osteomyelitis and invasive necrotizing pneumococcal infections. Previous research as revealed that PVL has the ability to induce apoptosis at low concentration (5nM-10nM) and necrosis (50-100nM) at high concentrations, with little detail on the mechanism of initiation. This research delineates concentrations dependent activation of programmed cell death as a factor of time, indicating a time dependent factor for inter-molecular communication between both mechanisms of cell death.

Comments

Copyright 2016 Heriberto DeLeon III. All Rights Reserved.

https://www.proquest.com/dissertations-theses/apoptotic-necrotizing-mechanisms-recombinant/docview/1810998770/se-2?accountid=7119

Recommended Citation

DeLeon, Heriberto III, "Apoptotic and necrotizing mechanisms of recombinant Panton-Valentine leukocidin in THP1 monocytes." (2016). Theses and Dissertations. 27.
https://scholarworks.utrgv.edu/etd/27