Date of Award
Master of Arts (MA)
Dr. Mario Gil
Dr. Upal Roy
Dr. Jason Popan
Neurological disorders like Parkinson’s Disease affect millions of individuals around the world. Parkinson’s Disease is associated with the degeneration of dopamine neurons in structures of the ventral midbrain, such as the substantia nigra and the ventral tegmental area. It is important to elucidate the neural mechanisms of neurological disorders for the development and application of pertinent therapies and treatments.
Here, we implemented a modified approach of stereological investigation to characterize and quantify the expression of tyrosine hydroxylase, a significant dopamine biomarker, in a neurotoxin-based animal model of PD. By doing so, we hope to better understand the structural components of the ventral midbrain and build on the current understanding of the role of dopamine in brain pathways that are implicated in neurological disorders like PD.
Vargas, Magaly, "Characterization and Quantification of Dopamine Neurons in the Ventral Midbrain: Implications for Neurological Disorders" (2020). Theses and Dissertations - UTRGV. 788.