Theses and Dissertations

Date of Award


Document Type


Degree Name

Master of Science (MS)


Manufacturing Engineering

First Advisor

Dr. Jianzhi Li

Second Advisor

Dr. Douglas Timmer

Third Advisor

Dr. Farid Ahmed


Printability is the ability to print a reproducible structure using the bioprinting technique. Constructing the relationships between printability and printing parameters of the extrusion printing process is difficult because of the presence of too many independent and inter-correlated factors. For this reason, it is necessary to identify and limit the number of significantly influential factors. In addition, Scaffold based blood vessel fabrication is a key challenge in 3D Bioprinting. As vascular smooth muscle cell (VSMCs) is a major component of blood vessels, the investigation of the behavior and orientation of VSMCs after printing is required to better understand the 3D bioprinting process of the blood vessel. This study fabricated a hollow tubular structure with human aortic smooth muscle cells using the co-axial extrusion printing method to observe the process compatibility. Response surface methodology (RSM) was used to find the optimum process parameters. The goal of this study was to ensure repeatable printing with the same dimension and consistency with these optimum process parameters. In the next phase, a cell-laden tubular structure was fabricated to observe the viability of vascular smooth muscle cells. In the future study, the orientation of the VSCMCs on the printed structure will be analyzed.


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