Theses and Dissertations

Date of Award


Document Type


Degree Name

Master of Science (MS)



First Advisor

Dr. Nirakar Sahoo

Second Advisor

Dr. Mohammed Farooqui

Third Advisor

Dr. Veerachandra K. Yemmireddy


Chapter 2: In this chapter, we have provided an update on the emerging role of ion channels in gastric acid secretion, emphasizing the modulation of cellular processes by transmembrane proteins and intracellular factors. It specifically focuses on the potential structural and functional role of transmembrane proteins present on the specialized cytoplasmic organelle called ‘tubulovesicle’ and their involvement in the signaling cascade of gastric acid secretion.

Chapter 3: In this chapter, we have explored a new form of autophagy, ‘Xenophagy,’ triggered by the invasion of intracellular pathogen. Xenophagy plays a crucial role in maintaining the gastrointestinal (GI) system and clearance of the virulent invading pathogen. We found a possible underlying mechanistic link of induction of xenophagy caused by an imbalance of gut microbes, mainly focused on commensal bacteria Escherichia coli (E. coli).

Chapter 4: In this chapter, we have investigated the impact of naturally occurring anthocyanin on gastric xenophagy. Our study found that It triggers the cell defense pathway via potntiation of lysosome biogenesis, further boosting xenophagy. Taken together, this thesis work proves an overview on how cellular signaling pathways, including organelles such as In summary, our results suggest that targeting lysosomal biogenesis and autophagic pathways could serve as a novel therapeutic strategy to treat diseases and disorders caused by invading pathogens via GI track and how naturally occurring, the anti-oxidant rich compound can effectively boost the cell defense mechanism and helps the cells to fight against the odds.


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