Theses and Dissertations
Molecular dynamic simulation studies of the androgen receptor complexed with 5α-dihydrotestosterone and an allosteric ligand
Date of Award
Master of Science (MS)
Dr. Evangelia Kotsikorou
Dr. Jose J. Gutierrez
Dr. Frank B. Dean
Receptors are important drug targets for the pharmaceutical industry, since they are involved in many illnesses. Nuclear receptors are a subset of receptors that control a variety of physiological events, by expression of genes from DNA. One of the nuclear receptors, the androgen receptor, is a steroid binding receptor that controls a variety of regulatory and development functions in the body. It is also the cause of some types of cancer, so the inhibition of this receptor is crucial. One of the processes studied to inhibit the function of the receptor is to see if an allosteric ligand, TRIAC, can bind to the BF-3 site, therefore inducing a change in the receptor and release of the endogenous ligand (DHT) before there is recruitment of other coactivators.
Villarreal, Everardo II, "Molecular dynamic simulation studies of the androgen receptor complexed with 5α-dihydrotestosterone and an allosteric ligand" (2016). Theses and Dissertations. 99.
Copyright 2016 Everardo Villarreal II. All Rights Reserved.