Host susceptibility to tuberculosis: insights from a longitudinal study of gene expression in diabetes

Authors

Hui-Qi Qu
Anne R. Rentfro, The University of Texas Rio Grande Valley
Yang Lu
Saraswathy Nair, The University of Texas Rio Grande Valley
Craig Hanis, University of Texas Health at Houston
Joseph B. Mccormick, University of Texas Health at Houston
Susan P. Fisher-Hoch, University of Texas Health at Houston

Document Type

Article

Publication Date

3-2012

Abstract

Tuberculosis (TB) remains a major global disease, and diabetes which is documented to increase susceptibility to TB threefold, is also becoming pandemic. This susceptibility has been attracting extensive research interest. The increased risk of TB in diabetes may serve as a unique model to understand host susceptibility to specific pathogens in humans. To examine this rationale, we investigated expression of reported TB candidate genes in a longitudinal diabetes study. Two genes HK2 and CD28 emerged as potential culprits in diabetes-increased TB susceptibility.

Comments

PMC Copyright notice

Recommended Citation

Qu, H. Q., Rentfro, A. R., Lu, Y., Nair, S., Hanis, C. L., McCormick, J. B., & Fisher-Hoch, S. P. (2012). Host susceptibility to tuberculosis: insights from a longitudinal study of gene expression in diabetes. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 16(3), 370–372. https://doi.org/10.5588/ijtld.11.0536

Publication Title

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

DOI

https://doi.org/10.5588/ijtld.11.0536