Document Type
Article
Publication Date
11-25-2024
Abstract
Growing evidence demonstrates the connection between gut microbiota, neurodevelopment, and adult brain function. Microbial colonization occurs before the maturation of neural systems and its association with brain development. The early microbiome interactions with the gut-brain axis evolved to stimulate cognitive activities. Gut dysbiosis can lead to impaired brain development, growth, and function. Docosahexaenoic acid (DHA) is critically required for brain structure and function, modulates gut microbiota, and impacts brain activity. This review explores how gut microbiota influences early brain development and adult functions, encompassing the modulation of neurotransmitter activity, neuroinflammation, and blood-brain barrier integrity. In addition, it highlights processes of how the gut microbiome affects fetal neurodevelopment and discusses adult brain disorders.
Recommended Citation
Mallick, R., Basak, S., Das, R. K., Banerjee, A., Paul, S., Pathak, S., & Duttaroy, A. K. (2024). Roles of the gut microbiota in human neurodevelopment and adult brain disorders. Frontiers in Neuroscience, 18, 1446700. https://doi.org/10.3389/fnins.2024.1446700
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Publication Title
Frontiers in Neuroscience
DOI
https://doi.org/10.3389/fnins.2024.1446700
Comments
Student publication.
© 2024 Mallick, Basak, Das, Banerjee, Paul, Pathak and Duttaroy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).